Genetic stratification of depression in UK Biobank.
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ABSTRACT:
SUBMITTER: Howard DM
PROVIDER: S-EPMC7246256 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Genetic stratification of depression in UK Biobank.
Howard David M DM Folkersen Lasse L Coleman Jonathan R I JRI Adams Mark J MJ Glanville Kylie K Werge Thomas T Hagenaars Saskia P SP Han Buhm B Porteous David D Campbell Archie A Clarke Toni-Kim TK Breen Gerome G Sullivan Patrick F PF Wray Naomi R NR Lewis Cathryn M CM McIntosh Andrew M AM
Translational psychiatry 20200524 1
Depression is a common and clinically heterogeneous mental health disorder that is frequently comorbid with other diseases and conditions. Stratification of depression may align sub-diagnoses more closely with their underling aetiology and provide more tractable targets for research and effective treatment. In the current study, we investigated whether genetic data could be used to identify subgroups within people with depression using the UK Biobank. Examination of cross-locus correlations were ...[more]
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