Mechanisms of Blood-Brain Barrier Dysfunction in Traumatic Brain Injury.
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ABSTRACT:
SUBMITTER: Cash A
PROVIDER: S-EPMC7246537 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Mechanisms of Blood-Brain Barrier Dysfunction in Traumatic Brain Injury.
Cash Alison A Theus Michelle H MH
International journal of molecular sciences 20200508 9
Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United States with roughly two million TBIs occurring annually. Due to the spectrum of severity and heterogeneity in TBIs, investigation into the secondary injury is necessary in order to formulate an effective treatment. A mechanical consequence of trauma involves dysregulation of the blood-brain barrier (BBB) which contributes to secondary injury and exposure of peripheral components to the brain parenchym ...[more]
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