Ontology highlight
ABSTRACT:
SUBMITTER: Navas A
PROVIDER: S-EPMC7246571 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Navas Arturo A Jannus Fatin F Fernández Belén B Cepeda Javier J Medina O'Donnell Marta M Díaz-Ruiz Luis L Sánchez-González Cristina C Llopis Juan J Seco José M JM Rufino-Palomares E E Lupiáñez José Antonio JA Gómez-Ruiz Santiago S Quiles José Luis JL Battino Maurizio M Choquesillo-Lazarte Duane D Ruiz-Muelle Ana Belén AB Fernández Ignacio I Reyes-Zurita Fernando F Rodríguez-Diéguez Antonio A
International journal of molecular sciences 20200429 9
We have designed and synthesized two novel cobalt coordination compounds using bumetanide (bum) and indomethacin (ind) therapeutic agents. The anti-inflammatory effects of cobalt metal complexes with ind and bum were assayed in lipopolysaccharide stimulated RAW 264.7 macrophages by inhibition of nitric oxide production. Firstly, we determined the cytotoxicity and the anti-inflammatory potential of the cobalt compounds and ind and bum ligands in RAW 264.7 cells. Indomethacin-based metal complex w ...[more]