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Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip.

ABSTRACT: Chronic infection with hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC). Novel treatments with direct-acting antivirals achieve high rates of sustained virologic response; however, the HCC risk remains elevated in cured patients, especially those with advanced liver disease. Long-term HCV infection causes a persistent and accumulating damage of the liver due to a combination of direct and indirect pro-oncogenic mechanisms. This review describes the processes involved in virus-induced disease progression by viral proteins, derailed signaling, immunity, and persistent epigenetic deregulation, which may be instrumental to develop urgently needed prognostic biomarkers and as targets for novel chemopreventive therapies.

SUBMITTER: Goto K

PROVIDER: S-EPMC7246584 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip.

Goto Kaku K Roca Suarez Armando Andres AA Wrensch Florian F Baumert Thomas F TF Lupberger Joachim J

International journal of molecular sciences 20200426 9

Chronic infection with hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC). Novel treatments with direct-acting antivirals achieve high rates of sustained virologic response; however, the HCC risk remains elevated in cured patients, especially those with advanced liver disease. Long-term HCV infection causes a persistent and accumulating damage of the liver due to a combination of direct and indirect pro-oncogenic mechanisms. This review describes the processes involved in ...[more]

PMID: 32357520

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