Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
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ABSTRACT:
SUBMITTER: Park H
PROVIDER: S-EPMC7247013 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
Park Hyungsun H Kang Ju-Hee JH Lee Seongju S
International journal of molecular sciences 20200510 9
Cells have developed elaborate quality-control mechanisms for proteins and organelles to maintain cellular homeostasis. Such quality-control mechanisms are maintained by conformational folding via molecular chaperones and by degradation through the ubiquitin-proteasome or autophagy-lysosome system. Accumulating evidence suggests that impaired autophagy contributes to the accumulation of intracellular inclusion bodies consisting of misfolded proteins, which is a hallmark of most neurodegenerative ...[more]
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