Comparison of Prostate-Specific Membrane Antigen Expression Levels in Human Salivary Glands to Non-Human Primates and Rodents.

ABSTRACT: Background: Prostate-specific membrane antigen (PSMA) has emerged as a promising target for developing radionuclide therapy (RNT) in prostate cancer; however, accumulation of PSMA-RNT in salivary glands can result in irreversible xerostomia. Methods to prevent PSMA-RNT-related xerostomia could be clinically useful; however, little is known about PSMA expression in salivary glands of preclinical animal models. Using [¹⁸F]DCFPyL autoradiography/biodistribution, PSMA expression levels were determined in salivary glands of various preclinical monkey and rodent species and compared with humans. Methods: Binding affinities (K_d) and PSMA levels (B_max) were determined by in vitro [¹⁸F]DCFPyL autoradiography studies.

SUBMITTER: Roy J 

PROVIDER: S-EPMC7247045 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature