Association between rs1800795 polymorphisms in the interleukin-6 gene and vasculitis: A meta-analysis.

ABSTRACT: Interleukin (IL)-6 is associated with the development and progression of vasculitis, and inhibitors of this cytokine are used to treat this disease. Polymorphisms of the promoter region of IL-6 are associated with the production and expression of IL-6. The aim of this study was to perform a meta-analysis of eligible studies to derive a precise estimate of the association between IL6 polymorphisms and susceptibility to vasculitis. A meta-analysis was conducted to identify the associations between IL6 rs1800795 (-174 G/C) polymorphisms and vasculitis. A total of 13 studies involving 1,294 vasculitis patients and 1,594 controls were considered in the meta-analysis. There were significant associations between IL6 rs1800795 polymorphisms and vasculitis in allele cont

SUBMITTER: Jung JH 

PROVIDER: S-EPMC7247089 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature