Methotrexate treatment efficacy in sarcoidosis might be related to TNF-α polymorphism: real life preliminary study.

ABSTRACT:

Introduction

Methotrexate therapy improves lung function in selected sarcoidosis patients. Variation in TNF gene was associated with response to treatment. Aim: To determine the predictive role of-308 G/A, -857C/T, -863 C/A and -1031 T/C TNF-α polymorphism in the efficacy of MTX for progressive pulmonary sarcoidosis.

Material and methods

Twenty-eight sarcoidosis patients treated with MTX (6-24 months) were genotyped for TNF-α polymorphisms: -1031 T/C, -857C/T, -308 G/A and -863 C/A. Pulmonary function test (PFT) were performed every 6 months to determine treatment response, until the drug withdrawal.

Results

No correlation between the initial clinical presentation of sarcoidosis and TNF α polymorphisms was found, neither for every allele no

SUBMITTER: Goljan Geremek A 

PROVIDER: S-EPMC7247097 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature