Ontology highlight
ABSTRACT:
SUBMITTER: Mechetin GV
PROVIDER: S-EPMC7247160 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Mechetin Grigory V GV Endutkin Anton V AV Diatlova Evgeniia A EA Zharkov Dmitry O DO
International journal of molecular sciences 20200428 9
DNA glycosylases are enzymes that initiate the base excision repair pathway, a major biochemical process that protects the genomes of all living organisms from intrinsically and environmentally inflicted damage. Recently, base excision repair inhibition proved to be a viable strategy for the therapy of tumors that have lost alternative repair pathways, such as BRCA-deficient cancers sensitive to poly(ADP-ribose)polymerase inhibition. However, drugs targeting DNA glycosylases are still in develop ...[more]