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Role of Endocannabinoids in Energy-Balance Regulation in Participants in the Postobese State-a PREVIEW Study.


ABSTRACT: Endocannabinoids are suggested to play a role in energy balance regulation. We aimed to investigate associations of endocannabinoid concentrations during the day with energy balance and adiposity and interactions with 2 diets differing in protein content in participants in the postobese phase with prediabetes. Participants (n = 38) were individually fed in energy balance with a medium protein (MP: 15:55:30% of energy from protein:carbohydrate:fat) or high-protein diet (HP: 25:45:30% energy from P:C:F) for 48 hours in a respiration chamber. Associations between energy balance, energy expenditure, respiratory quotient, and endocannabinoid concentrations during the day were assessed. Plasma-concentrations of anandamide (AEA), oleoylethanolamide (OEA), palmitoyethanolamide (PEA), and pregnenolone (PREG) significantly decreased during the day. This decrease was inversely related to body mass index (AEA) or body fat (%) (PEA; OEA). The lowest RQ value, before lunch, was inversely associated with concentrations of AEA and PEA before lunch. Area under the curve (AUC) of concentrations of AEA, 2-AG, PEA, and OEA were positively related to body fat% (P < .05).The HP and MP groups showed no differences in concentrations of AEA, OEA, PEA, and PREG, but the AUC of 2-arachidonoylglycerol (2-AG) was significantly higher in the HP vs the MP group. In energy balance, only the endocannabinoid 2-AG changed in relation to protein level of the diet, whereas the endocannabinoid AEA and endocannabinoid-related compounds OEA and PEA reflected the gradual energy intake matching energy expenditure during the day.

SUBMITTER: Drummen M 

PROVIDER: S-EPMC7247554 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Role of Endocannabinoids in Energy-Balance Regulation in Participants in the Postobese State-a PREVIEW Study.

Drummen Mathijs M   Tischmann Lea L   Gatta-Cherifi Blandine B   Cota Daniela D   Matias Isabelle I   Raben Anne A   Adam Tanja T   Westerterp-Plantenga Margriet M  

The Journal of clinical endocrinology and metabolism 20200701 7


<h4>Context</h4>Endocannabinoids are suggested to play a role in energy balance regulation.<h4>Objective</h4>We aimed to investigate associations of endocannabinoid concentrations during the day with energy balance and adiposity and interactions with 2 diets differing in protein content in participants in the postobese phase with prediabetes.<h4>Design and participants</h4>Participants (n = 38) were individually fed in energy balance with a medium protein (MP: 15:55:30% of energy from protein:ca  ...[more]

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