Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis.
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ABSTRACT:
SUBMITTER: Ohtsuki T
PROVIDER: S-EPMC7247684 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis.
Ohtsuki Takashi T Hatipoglu Omer F OF Asano Keiichi K Inagaki Junko J Nishida Keiichiro K Hirohata Satoshi S
International journal of molecular sciences 20200429 9
In patients with osteoarthritis (OA), there is a decrease in both the concentration and molecular size of hyaluronan (HA) in the synovial fluid and cartilage. Cell migration-inducing hyaluronidase 1 (CEMIP), also known as hyaluronan (HA)-binding protein involved in HA depolymerization (HYBID), was recently reported as an HA depolymerization-related molecule expressed in the cartilage of patients with OA. However, the underlying mechanism of CEMIP regulation is not well understood. We found that ...[more]
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