Ontology highlight
ABSTRACT:
SUBMITTER: Wietecha MS
PROVIDER: S-EPMC7248062 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Wietecha Mateusz S MS Pensalfini Marco M Cangkrama Michael M Müller Bettina B Jin Juyoung J Brinckmann Jürgen J Mazza Edoardo E Werner Sabine S
Nature communications 20200525 1
Matrix deposition is essential for wound repair, but when excessive, leads to hypertrophic scars and fibrosis. The factors that control matrix deposition in skin wounds have only partially been identified and the consequences of matrix alterations for the mechanical properties of wounds are largely unknown. Here, we report how a single diffusible factor, activin A, affects the healing process across scales. Bioinformatics analysis of wound fibroblast transcriptome data combined with biochemical ...[more]