Ontology highlight
ABSTRACT:
SUBMITTER: ElInati E
PROVIDER: S-EPMC7248069 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
ElInati Elias E Zielinska Agata P AP McCarthy Afshan A Kubikova Nada N Maciulyte Valdone V Mahadevaiah Shantha S Sangrithi Mahesh N MN Ojarikre Obah O Wells Dagan D Niakan Kathy K KK Schuh Melina M Turner James M A JMA
Nature communications 20200525 1
DNA double-strand breaks (DSBs) are toxic to mammalian cells. However, during meiosis, more than 200 DSBs are generated deliberately, to ensure reciprocal recombination and orderly segregation of homologous chromosomes. If left unrepaired, meiotic DSBs can cause aneuploidy in gametes and compromise viability in offspring. Oocytes in which DSBs persist are therefore eliminated by the DNA-damage checkpoint. Here we show that the DNA-damage checkpoint eliminates oocytes via the pro-apoptotic BCL-2 ...[more]