Ontology highlight
ABSTRACT:
SUBMITTER: Kadota S
PROVIDER: S-EPMC7248104 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature communications 20200525 1
Nucleoporin proteins (Nups) have been proposed to mediate spatial and temporal chromatin organization during gene regulation. Nevertheless, the molecular mechanisms in mammalian cells are not well understood. Here, we report that Nucleoporin 153 (NUP153) interacts with the chromatin architectural proteins, CTCF and cohesin, and mediates their binding across cis-regulatory elements and TAD boundaries in mouse embryonic stem (ES) cells. NUP153 depletion results in altered CTCF and cohesin binding ...[more]