Ulmus parvifolia Modulates Platelet Functions and Inhibits Thrombus Formation by Regulating Integrin α_IIbβ₃ and cAMP Signaling.

ABSTRACT:

Background

The prevalence of cardiovascular diseases (CVDs) is increasing at a high rate, and the available treatment options, sometimes, have complications which necessitates the need to develop safer and efficacious approaches. Ethnomedicinal applications reportedly reduce CVD risk. Ulmus parvifolia Jacq. (Ulmaceae) commonly known as Chinese Elm or Lacebark Elm, is native to China, Japan, and Korea. It exhibits anti-inflammatory, antiviral, and anticancer properties, but its anti-platelet properties have not yet been elucidated.

Purpose

To investigate the pharmacological anti-platelet and anti-thrombotic effects of U. parvifolia bark extract.

Study design and methods

Human and rat washed platelets were prepared; light transmission aggregometry and scan

SUBMITTER: Irfan M 

PROVIDER: S-EPMC7248206 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature