Dataset Information

Analysis of Postural Control Using Principal Component Analysis: The Relevance of Postural Accelerations and of Their Frequency Dependency for Selecting the Number of Movement Components.

ABSTRACT: One criterion when selecting the number of principal components (PCs) to be considered in a principal component analysis (PCA) is the fraction of overall variance that each PC represents. When applying a PCA to kinematic marker data in postural control research, this criterion relates to the amplitude of postural changes, recently often called "principal (postural) positions" (PPs). However, in the assessment of postural control, important aspects are also how fast posture changes and the acceleration of postural changes, i.e., "principal accelerations" (PAs). The current study compared how much of the total position variance each PP explained (PP_rVAR) and how much of the total acceleration variance each PA explained (PA_rVAR). Furthermore, the frequency content of PP and PA signals were evaluated. Postural movements of 26 participants standing on stable ground or balancing on a multiaxial balance board were analyzed by applying a PCA on 90 marker coordinates. For each PC, PP_rVAR, PA_rVAR, and the Fourier transformations of the PP and PA time series were calculated. The PP_rVAR and the PA_rVAR-distributions differed substantially. The PP-frequency domain was observed well below 5 Hz, the PA-frequency domain up to 5 Hz for stable standing and up to 10 Hz on the balance board. These results confirm that small-amplitude but fast movement components can have a higher impact on postural accelerations-and thus on the forces active in the system-than large-amplitude but slow lower-order movement components. Thus, PA variance and its dependence on filter frequencies should be considered in dimensionality reduction decisions.

SUBMITTER: Promsri A

PROVIDER: S-EPMC7248432 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Analysis of Postural Control Using Principal Component Analysis: The Relevance of Postural Accelerations and of Their Frequency Dependency for Selecting the Number of Movement Components.

Promsri Arunee A Federolf Peter P

Frontiers in bioengineering and biotechnology 20200519

One criterion when selecting the number of principal components (PCs) to be considered in a principal component analysis (PCA) is the fraction of overall variance that each PC represents. When applying a PCA to kinematic marker data in postural control research, this criterion relates to the amplitude of postural changes, recently often called "principal (postural) positions" (PPs). However, in the assessment of postural control, important aspects are also how fast posture changes and the accele ...[more]

PMID: 32509755

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Project description:BackgroundFetal movement (FM) counting is a simple and widely used method of assessing fetal well-being. However, little is known about what women perceive as decreased fetal movement (DFM) and how maternally perceived DFM is reflected in FM charts.MethodsWe analyzed FM counting data from 148 DFM events occurring in 137 pregnancies. The women counted FM daily from pregnancy week 24 until birth using a modified count-to-ten procedure. Common temporal patterns for the two weeks preceding hospital examination due to DFM were extracted from the FM charts using wavelet principal component analysis; a statistical methodology particularly developed for modeling temporal data with sudden changes, i.e. spikes that are frequently found in FM data. The association of the extracted temporal patterns with fetal complications was assessed by including the individuals' scores on the wavelet principal components as explanatory variables in multivariable logistic regression analyses for two outcome measures: (i) complications identified during DFM-related consultations (n = 148) and (ii) fetal compromise at the time of consultation (including relevant information about birth outcome and placental pathology). The latter outcome variable was restricted to the DFM events occurring within 21 days before birth (n = 76).ResultsAnalyzing the 148 and 76 DFM events, the first three main temporal FM counting patterns explained 87.2% and 87.4%, respectively, of all temporal variation in the FM charts. These three temporal patterns represented overall counting times, sudden spikes around the time of DFM events, and an inverted U-shaped pattern, explaining 75.3%, 8.6%, and 3.3% and 72.5%, 9.6%, and 5.3% of variation in the total cohort and subsample, respectively. Neither of the temporal patterns was significantly associated with the two outcome measures.ConclusionsAcknowledging that sudden, large changes in fetal activity may be underreported in FM charts, our study showed that the temporal FM counting patterns in the two weeks preceding DFM-related consultation contributed little to identify clinically important changes in perceived FM. It thus provides insufficient information for giving detailed advice to women on when to contact health care providers. The importance of qualitative features of maternally perceived DFM should be further explored.

Project description:BackgroundPrincipal component analysis is used to summarize matrix data, such as found in transcriptome, proteome or metabolome and medical examinations, into fewer dimensions by fitting the matrix to orthogonal axes. Although this methodology is frequently used in multivariate analyses, it has disadvantages when applied to experimental data. First, the identified principal components have poor generality; since the size and directions of the components are dependent on the particular data set, the components are valid only within the data set. Second, the method is sensitive to experimental noise and bias between sample groups. It cannot reflect the experimental design that is planned to manage the noise and bias; rather, it estimates the same weight and independence to all the samples in the matrix. Third, the resulting components are often difficult to interpret. To address these issues, several options were introduced to the methodology. First, the principal axes were identified using training data sets and shared across experiments. These training data reflect the design of experiments, and their preparation allows noise to be reduced and group bias to be removed. Second, the center of the rotation was determined in accordance with the experimental design. Third, the resulting components were scaled to unify their size unit.ResultsThe effects of these options were observed in microarray experiments, and showed an improvement in the separation of groups and robustness to noise. The range of scaled scores was unaffected by the number of items. Additionally, unknown samples were appropriately classified using pre-arranged axes. Furthermore, these axes well reflected the characteristics of groups in the experiments. As was observed, the scaling of the components and sharing of axes enabled comparisons of the components beyond experiments. The use of training data reduced the effects of noise and bias in the data, facilitating the physical interpretation of the principal axes.ConclusionsTogether, these introduced options result in improved generality and objectivity of the analytical results. The methodology has thus become more like a set of multiple regression analyses that find independent models that specify each of the axes.

Dataset Information

Analysis of Postural Control Using Principal Component Analysis: The Relevance of Postural Accelerations and of Their Frequency Dependency for Selecting the Number of Movement Components.

Publications

Analysis of Postural Control Using Principal Component Analysis: The Relevance of Postural Accelerations and of Their Frequency Dependency for Selecting the Number of Movement Components.

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