Potential of mesenchymal stem cells alone, or in combination, to treat traumatic brain injury.

ABSTRACT: Traumatic brain injury (TBI) causes death and disability in the United States and around the world. The traumatic insult causes the mechanical injury of the brain and primary cellular death. While a comprehensive pathological mechanism of TBI is still lacking, the focus of the TBI research is concentrated on understanding the pathophysiology and developing suitable therapeutic approaches. Given the complexities in pathophysiology involving interconnected immunologic, inflammatory, and neurological cascades occurring after TBI, the therapies directed to a single mechanism fail in the clinical trials. This has led to the development of the paradigm of a combination therapeutic approach against TBI. While there are no drugs available for the treatment of TBI, stem cell therapy has shown promi

SUBMITTER: Willing AE 

PROVIDER: S-EPMC7248546 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature