Trifluoromethoxypyrazines: Preparation and Properties.
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ABSTRACT:
SUBMITTER: Sokolenko TM
PROVIDER: S-EPMC7248996 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
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Trifluoromethoxypyrazines: Preparation and Properties.
Sokolenko Taras M TM Yagupolskii Yurii L YL
Molecules (Basel, Switzerland) 20200509 9
The incorporation of the trifluoromethoxy group into organic molecules has become very popular due to the unique properties of the named substituent that has a "pseudohalogen" character, while the chemical properties of the synthesized compound, especially heterocycles with such a group, are less studied. As trifluoromethoxy-substituted pyrazines are still unknown, we have developed efficient and scalable methods for 2-chloro-5-trifluoromethoxypyrazine synthesis, showing the synthetic utility of ...[more]
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