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A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives.

ABSTRACT: The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation.

SUBMITTER: Gambacorta G

PROVIDER: S-EPMC7249113 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives.

Gambacorta Guido G Apperley David C DC Baxendale Ian R IR

Molecules (Basel, Switzerland) 20200505 9

The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation. ...[more]

PMID: 32380725

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