Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura N
PROVIDER: S-EPMC7249185 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nakamura Noriaki N Uchinomiya Shohei S Inoue Kazuya K Ojida Akio A
Molecules (Basel, Switzerland) 20200505 9
Self-immolative linker is a useful building block of molecular probes, with broad applications in the fields of enzyme activity analysis, stimuli-responsive material science, and drug delivery. This manuscript presents N-methyl dimethyl methyl (i.e., trimethyl) carbamate as a new class of self-immolative linker for the fluorescence detection of enzyme reactions. The trimethyl carbamate was shown to spontaneously undergo intramolecular cyclization upon formation of a carboxylate group, to liberat ...[more]