Long term N-acetylcysteine administration rescues liver steatosis via endoplasmic reticulum stress with unfolded protein response in mice.

ABSTRACT: BACKGROUND:Fat accumulation in the liver contributes to the development of non-alcoholic fatty liver disease (NAFLD). N-acetylcysteine (NAC) is an antioxidant, acting both directly and indirectly via upregulation of cellular antioxidants. We examined the mechanisms of liver steatosis after 12?months high fat (HF) diet and tested the ability of NAC to rescue liver steatosis. METHODS:Seven-week-old C57BL/6 (B6) male mice were administered HF diet for 12?months (HF group). Two other groups received HF diet for 12?months accompanied by NAC for 12?months (HFD?+?NAC(1-12)) or 6?months (HFD?+?NAC(1-6)). The control group was fed regular diet for 12?months (CD group). RESULTS:Liver steatosis was more pronounced in the HF group than in the CD group after 12?month feeding. NAC intake for 6 or 12?months decreased liver steatosis in comparison with HF diet (p?

SUBMITTER: Tsai CC 

PROVIDER: S-EPMC7249367 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature