A Randomized, Placebo-Controlled, Double-Blind Study of Minocycline for Reducing the Symptom Burden Experienced by Patients With Advanced Pancreatic Cancer.

ABSTRACT:

Context

Although it is well known that patients with advanced pancreatic cancer (PC) experience significant symptom burden, few strategies for effective symptom intervention are available for them.

Objectives

To investigate the efficacy of minocycline, an anti-inflammatory agent, for symptom reduction in patients with advanced PC.

Methods

We conducted Phase II, randomized, and placebo-controlled trial to obtain preliminary estimates of the effects on symptom reduction with 100 mg of minocycline or placebo given twice a day. Eligible patients had diagnosed advanced PC and were scheduled for standard chemotherapy. Patient-reported symptoms were measured weekly during the eight-week trial using the MD Anderson Symptom Inventory (MDASI) module in patients with gastrointes

SUBMITTER: Kamal M 

PROVIDER: S-EPMC7249481 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature