Ontology highlight
ABSTRACT:
SUBMITTER: Hantisteanu S
PROVIDER: S-EPMC7250423 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Hantisteanu Shay S Dicken Yosef Y Negreanu Varda V Goldenberg Dalia D Brenner Ori O Leshkowitz Dena D Lotem Joseph J Levanon Ditsa D Groner Yoram Y
PloS one 20200526 5
Mice deficient in the transcription factor Runx3 develop a multitude of immune system defects, including early onset colitis. This paper demonstrates that Runx3 is expressed in colonic mononuclear phagocytes (MNP), including resident macrophages (RM) and dendritic cell subsets (cDC2). Runx3 deletion in MNP causes early onset colitis due to their impaired maturation. Mechanistically, the resulting MNP subset imbalance leads to up-regulation of pro-inflammatory genes as occurs in IL10R-deficient R ...[more]