Ontology highlight
ABSTRACT:
SUBMITTER: Pirouz M
PROVIDER: S-EPMC7250864 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Pirouz Mehdi M Wang Chih-Hao CH Liu Qi Q Ebrahimi Aref G AG Shamsi Farnaz F Tseng Yu-Hua YH Gregory Richard I RI
Nature communications 20200526 1
DIS3L2-mediated decay (DMD) is a surveillance pathway for certain non-coding RNAs (ncRNAs) including ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), and RMRP. While mutations in DIS3L2 are associated with Perlman syndrome, the biological significance of impaired DMD is obscure and pathological RNAs have not been identified. Here, by ribosome profiling (Ribo-seq) we find specific dysregulation of endoplasmic reticulum (ER)-targeted mRNA translation in DIS3L2-deficient ...[more]