Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways.

ABSTRACT:

Background

Smoking and alcohol increase risk for colorectal malignancies. However, colorectal cancer (CRC) is a heterogenic disease and associations with the molecular pathological pathways are unclear.

Methods

This population-based case-control study includes 2444 cases with first-diagnosis CRC and 2475 controls. Tumour tissue was analysed for MSI (microsatellite instability), CIMP (CpG island methylator phenotype), BRAF (B-Raf proto-oncogene serine/threonine kinase gene) and KRAS (Kirsten rat sarcoma viral oncogene homologue gene) mutations. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated for associations between alcohol and smoking and CRC molecular subtypes and pathways.

Results

Current smoking showed higher ORs for MSI-high (OR = 2.79, 95%

SUBMITTER: Amitay EL 

PROVIDER: S-EPMC7250912 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature