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Management of atypical chronic lymphocytic leukemia presenting with extreme leukocytosis.


ABSTRACT: Atypical chronic lymphocytic lymphoma (CLL) with CCND1 translocation is poorly described, particularly in the era of modern inhibitors of the B-cell receptor pathway. We present a patient with atypical CLL who had a significant response to ibrutinib, highlighting the effectiveness of this agent in higher risk CLL subgroups.

SUBMITTER: Muddasani R 

PROVIDER: S-EPMC7250984 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Management of atypical chronic lymphocytic leukemia presenting with extreme leukocytosis.

Muddasani Ramya R   Talwar Neel N   Suarez-Londono Jaime Andres JA   Braunstein Marc M  

Clinical case reports 20200305 5


Atypical chronic lymphocytic lymphoma (CLL) with CCND1 translocation is poorly described, particularly in the era of modern inhibitors of the B-cell receptor pathway. We present a patient with atypical CLL who had a significant response to ibrutinib, highlighting the effectiveness of this agent in higher risk CLL subgroups. ...[more]

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