Primary cilia mediate Klf2-dependant Notch activation in regenerating heart.
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ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC7251007 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Primary cilia mediate Klf2-dependant Notch activation in regenerating heart.
Li Xueyu X Lu Qiang Q Peng Yuanyuan Y Geng Fang F Shao Xuelian X Zhou Huili H Cao Ying Y Zhang Ruilin R
Protein & cell 20200405 6
Unlike adult mammalian heart, zebrafish heart has a remarkable capacity to regenerate after injury. Previous study has shown Notch signaling activation in the endocardium is essential for regeneration of the myocardium and this activation is mediated by hemodynamic alteration after injury, however, the molecular mechanism has not been fully explored. In this study we demonstrated that blood flow change could be perceived and transmitted in a primary cilia dependent manner to control the hemodyna ...[more]
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