Regulatory T Cell Extracellular Vesicles Modify T-Effector Cell Cytokine Production and Protect Against Human Skin Allograft Damage.
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ABSTRACT:
SUBMITTER: Tung SL
PROVIDER: S-EPMC7251034 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Regulatory T Cell Extracellular Vesicles Modify T-Effector Cell Cytokine Production and Protect Against Human Skin Allograft Damage.
Tung Sim Lai SL Fanelli Giorgia G Matthews Robert Ian RI Bazoer Jordan J Letizia Marilena M Vizcay-Barrena Gema G Faruqu Farid N FN Philippeos Christina C Hannen Rosalind R Al-Jamal Khuloud T KT Lombardi Giovanna G Smyth Lesley Ann LA
Frontiers in cell and developmental biology 20200520
Regulatory T cells (Tregs) are a subpopulation of CD4<sup>+</sup> T cells with a fundamental role in maintaining immune homeostasis and inhibiting unwanted immune responses using several different mechanisms. Recently, the intercellular transfer of molecules between Tregs and their target cells has been shown via trogocytosis and the release of small extracellular vesicles (sEVs). In this study, CD4<sup>+</sup>CD25<sup>+</sup>CD127<sup>lo</sup> human Tregs were found to produce sEVs capable of i ...[more]
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