Ontology highlight
ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC7251150 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Li Chaohong C Zhao Baosheng B Fan Ya-Nan YN Jia Xianglei X Liu Yuzhen Y
Frontiers in physiology 20200520
This study explored the expression of BACE1 (β-amyloid precursor protein cleaving enzyme 1) in the rat carotid body and the effect of CIH (cyclic intermittent hypoxia) on the expression of BACE1. We found that BACE1 was expressed in the rat carotid body and located in the nerve endings and type II cells but not in type I cells. CIH reduced BACE1 level in the carotid body, and reoxygenation or ROS scavenger alleviated this reduction. Furthermore, we found that CIH augmented the mRNA level of PGC- ...[more]