Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure.
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ABSTRACT:
SUBMITTER: Dyavanapalli J
PROVIDER: S-EPMC7251188 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
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Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure.
Dyavanapalli Jhansi J Rodriguez Jeannette J Rocha Dos Santos Carla C Escobar Joan B JB Dwyer Mary Kate MK Schloen John J Lee Kyung-Min KM Wolaver Whitney W Wang Xin X Dergacheva Olga O Michelini Lisete C LC Schunke Kathryn J KJ Spurney Christopher F CF Kay Matthew W MW Mendelowitz David D
JACC. Basic to translational science 20200525 5
This work shows long-term restoration of the hypothalamic oxytocin (OXT) network preserves OXT release, reduces mortality, cardiac inflammation, fibrosis, and improves autonomic tone and cardiac function in a model of heart failure. Intranasal administration of OXT in patients mimics the short-term changes seen in animals by increasing parasympathetic-and decreasing sympathetic-cardiac activity. This work provides the essential translational foundation to determine if approaches that mimic parav ...[more]
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