Ontology highlight
ABSTRACT:
SUBMITTER: Siouda M
PROVIDER: S-EPMC7251929 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
iScience 20200506 6
Epigenetic deregulation of gene transcription is central to cancer cell plasticity and malignant progression but remains poorly understood. We found that the uncharacterized epigenetic factor chromodomain on Y-like 2 (CDYL2) is commonly over-expressed in breast cancer, and that high CDYL2 levels correlate with poor prognosis. Supporting a functional role for CDYL2 in malignancy, it positively regulated breast cancer cell migration, invasion, stem-like phenotypes, and epithelial-to-mesenchymal tr ...[more]