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Interfacial bioconjugation on emulsion droplet for biosensors.


ABSTRACT: Interfacial bioconjugation methods are developed for intact liquid emulsion droplets. Complex emulsion droplets having internal hydrocarbon and fluorocarbon immiscible structured phases maintain a dynamic interface for controlled interfacial reactivity. The internal morphological change after binding to biomolecules is readily visualized and detected by light transmission, which provides a platform for the formation of inexpensive and portable bio-sensing assays for enzymes, antibodies, nucleic acids and carbohydrates.

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC7251934 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Interfacial bioconjugation on emulsion droplet for biosensors.

Zhang Qifan Q   Scigliano Anita A   Biver Tarita T   Pucci Andrea A   Swager Timothy M TM  

Bioorganic & medicinal chemistry 20180413 19


Interfacial bioconjugation methods are developed for intact liquid emulsion droplets. Complex emulsion droplets having internal hydrocarbon and fluorocarbon immiscible structured phases maintain a dynamic interface for controlled interfacial reactivity. The internal morphological change after binding to biomolecules is readily visualized and detected by light transmission, which provides a platform for the formation of inexpensive and portable bio-sensing assays for enzymes, antibodies, nucleic  ...[more]

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