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Interfacial bioconjugation on emulsion droplet for biosensors.

ABSTRACT: Interfacial bioconjugation methods are developed for intact liquid emulsion droplets. Complex emulsion droplets having internal hydrocarbon and fluorocarbon immiscible structured phases maintain a dynamic interface for controlled interfacial reactivity. The internal morphological change after binding to biomolecules is readily visualized and detected by light transmission, which provides a platform for the formation of inexpensive and portable bio-sensing assays for enzymes, antibodies, nucleic acids and carbohydrates.

SUBMITTER: Zhang Q

PROVIDER: S-EPMC7251934 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Interfacial bioconjugation on emulsion droplet for biosensors.

Zhang Qifan Q Scigliano Anita A Biver Tarita T Pucci Andrea A Swager Timothy M TM

Bioorganic & medicinal chemistry 20180413 19

Interfacial bioconjugation methods are developed for intact liquid emulsion droplets. Complex emulsion droplets having internal hydrocarbon and fluorocarbon immiscible structured phases maintain a dynamic interface for controlled interfacial reactivity. The internal morphological change after binding to biomolecules is readily visualized and detected by light transmission, which provides a platform for the formation of inexpensive and portable bio-sensing assays for enzymes, antibodies, nucleic ...[more]

PMID: 29691155

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