Dataset Information

Methodology for the American Society of Hematology VTE guidelines: current best practice, innovations, and experiences.

ABSTRACT: Background: Methods for the development of clinical guidelines have advanced dramatically over the past 2 decades to strive for trustworthiness, transparency, user-friendliness, and rigor. The American Society of Hematology (ASH) guidelines on venous thromboembolism (VTE) have followed these advances, together with application of methodological innovations.

Objective: In this article, we describe methods and methodological innovations as a model to inform future guideline enterprises by ASH and others to achieve guideline standards. Methodological innovations introduced in the development of the guidelines aim to address current challenges in guideline development.

Methods: We followed ASH policy for guideline development, which is based on the Guideline International Network (GIN)-McMaster Guideline Development Checklist and current best practices. Central coordination, specialist working groups, and expert panels were established for the development of 10 VTE guidelines. Methodological guidance resources were developed to guide the process across guidelines panels. A methods advisory group guided the development and implementation of methodological innovations to address emerging challenges and needs.

Results: The complete set of VTE guidelines will include >250 recommendations. Methodological innovations include the use of health-outcome descriptors, online voting with guideline development software, modeling of pathways for diagnostic questions, application of expert evidence, and a template manuscript for publication of ASH guidelines. These methods advance guideline development standards and have already informed other ASH guideline projects.

Conclusions: The development of the ASH VTE guidelines followed rigorous methods and introduced methodological innovations during guideline development, striving for the highest possible level of trustworthiness, transparency, user-friendliness, and rigor.

SUBMITTER: Wiercioch W

PROVIDER: S-EPMC7252554 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Methodology for the American Society of Hematology VTE guidelines: current best practice, innovations, and experiences.

Wiercioch Wojtek W Nieuwlaat Robby R Akl Elie A EA Kunkle Robert R Alexander Kendall E KE Cuker Adam A Rajasekhar Anita A Alonso-Coello Pablo P Anderson David R DR Bates Shannon M SM Cushman Mary M Dahm Philipp P Guyatt Gordon G Iorio Alfonso A Lim Wendy W Lyman Gary H GH Middeldorp Saskia S Monagle Paul P Mustafa Reem A RA Neumann Ignacio I Ortel Thomas L TL Rochwerg Bram B Santesso Nancy N Vesely Sara K SK Witt Daniel M DM Schünemann Holger J HJ

Blood advances 20200501 10

<h4>Background</h4>Methods for the development of clinical guidelines have advanced dramatically over the past 2 decades to strive for trustworthiness, transparency, user-friendliness, and rigor. The American Society of Hematology (ASH) guidelines on venous thromboembolism (VTE) have followed these advances, together with application of methodological innovations.<h4>Objective</h4>In this article, we describe methods and methodological innovations as a model to inform future guideline enterprise ...[more]

PMID: 32453843

Similar Datasets

Project description:BACKGROUND:The management of acute and chronic pain for individuals living with sickle cell disease (SCD) is a clinical challenge. This reflects the paucity of clinical SCD pain research and limited understanding of the complex biological differences between acute and chronic pain. These issues collectively create barriers to effective, targeted interventions. Optimal pain management requires interdisciplinary care. OBJECTIVE:These evidence-based guidelines developed by the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in pain management decisions for children and adults with SCD. METHODS:ASH formed a multidisciplinary panel, including 2 patient representatives, that was thoroughly vetted to minimize bias from conflicts of interest. The Mayo Evidence-Based Practice Research Program supported the guideline development process, including updating or performing systematic reviews. Clinical questions and outcomes were prioritized according to importance for clinicians and patients. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used, including GRADE evidence-to-decision frameworks, to assess evidence and make recommendations, which were subject to public comment. RESULTS:The panel reached consensus on 18 recommendations specific to acute and chronic pain. The recommendations reflect a broad pain management approach, encompassing pharmacological and nonpharmacological interventions and analgesic delivery. CONCLUSIONS:Because of low-certainty evidence and closely balanced benefits and harms, most recommendations are conditional. Patient preferences should drive clinical decisions. Policymaking, including that by payers, will require substantial debate and input from stakeholders. Randomized controlled trials and comparative-effectiveness studies are needed for chronic opioid therapy, nonopioid therapies, and nonpharmacological interventions.

Dataset Information

Methodology for the American Society of Hematology VTE guidelines: current best practice, innovations, and experiences.

Publications

Methodology for the American Society of Hematology VTE guidelines: current best practice, innovations, and experiences.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets