Ontology highlight
ABSTRACT:
SUBMITTER: Pai RL
PROVIDER: S-EPMC7253017 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Pai Ruth-Anne Langan RL Japp Alberto Sada AS Gonzalez Michael M Rasheed Rozena F RF Okumura Mariko M Arenas Daniel D Pierson Sheila K SK Powers Victoria V Layman Awo Akosua Kesewa AAK Kao Charlly C Hakonarson Hakon H van Rhee Frits F Betts Michael R MR Kambayashi Taku T Fajgenbaum David C DC
JCI insight 20200507 9
The TAFRO clinical subtype of idiopathic multicentric Castleman disease (iMCD-TAFRO) is a rare hematologic illness involving episodic disease flares of thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly (TAFRO) and progressive multiple organ dysfunction. We previously showed that the mTOR signaling pathway is elevated in lymph nodes of iMCD-TAFRO patients and that an mTOR inhibitor is effective in a small cohort of patients. However, the upstream mech ...[more]