Ontology highlight
ABSTRACT:
SUBMITTER: Debebe BJ
PROVIDER: S-EPMC7253178 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Debebe Bisrat J BJ Boelen Lies L Lee James C JC Thio Chloe L CL Astemborski Jacquie J Kirk Gregory G Khakoo Salim I SI Donfield Sharyne M SM Goedert James J JJ Asquith Becca B
eLife 20200402
Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for understanding the etiology of human disease. HLA class I associations are often interpreted in the light of 'protective' or 'detrimental' CD8<sup>+</sup> T cell responses which are restricted by the host HLA class I allotype. However, given the diverse receptors which are bound ...[more]