Dataset Information

Digital arterial pressure pulse wave analysis and cardiovascular events in the general population: the Prevention of Renal and Vascular End-stage Disease study.

ABSTRACT: BACKGROUND:Arterial stiffness influences the contour of the digital pressure pulse wave. METHOD:Here, we investigated whether the digital pulse propagation index (DPPI), based on the digital pressure pulse wave, DPPI is associated with cardiovascular events, heart failure, and mortality in a large population-based cohort. Between 2001 and 2003, DPPI was measured with a PortaPres noninvasive hemodynamic monitoring device (FinaPres Medical Systems, Amsterdam, The Netherlands) in participants of the Prevention of Renal and Vascular End-stage Disease study, a community-based cohort. We assessed the main determinants of the DPPI and investigated associations of DPPI with cardiovascular events and mortality. RESULTS:The study included 5474 individuals. Mean age was 52.3?±?11.8 years and 50.5% was male. Median baseline DPPI was 5.81?m/s (interquartile range 5.47-6.20). Higher age, mean arterial blood pressure, body height, heart rate, current smoking, and lower HDL cholesterol levels and waist circumference were independent determinants of the DPPI (r?=?0.43). After adjustment for heart rate, highlogDPPI was associated with all-cause mortality [hazard ratio: 1.67, 95% confidence interval (1.55-1.81) per SD; P?

SUBMITTER: De Jong MA

PROVIDER: S-EPMC7253183 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Digital arterial pressure pulse wave analysis and cardiovascular events in the general population: the Prevention of Renal and Vascular End-stage Disease study.

De Jong Maarten A MA Van Roon Arie M AM Bakker Jens T JT Bijen Hendrik T J HTJ Mulder Douwe J DJ Brouwers Frank P FP Van Gilst Wiek H WH Voors Adriaan A AA Gansevoort Ron T RT Bakker Stephan J L SJL De Borst Martin H MH

Journal of hypertension 20200601 6

<h4>Background</h4>Arterial stiffness influences the contour of the digital pressure pulse wave.<h4>Method</h4>Here, we investigated whether the digital pulse propagation index (DPPI), based on the digital pressure pulse wave, DPPI is associated with cardiovascular events, heart failure, and mortality in a large population-based cohort. Between 2001 and 2003, DPPI was measured with a PortaPres noninvasive hemodynamic monitoring device (FinaPres Medical Systems, Amsterdam, The Netherlands) in par ...[more]

PMID: 32371796

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Project description:OBJECTIVE:Assessment of local arterial properties has become increasingly important in cardiovascular research as well as in clinical domains. Vascular wall stiffness indices are related to local pulse pressure (?P) level, mechanical and geometrical characteristics of the arterial vessel. Non-invasive evaluation of local ?P from the central arteries (aorta and carotid) is not straightforward in a non-specialist clinical setting. In this work, we present a method and system for real-time and beat-by-beat evaluation of local ?P from superficial arteries-a non-invasive, cuffless and calibration-free technique. METHODS:The proposed technique uses a bi-modal arterial compliance probe which consisted of two identical magnetic plethysmograph (MPG) sensors located at 23 mm distance apart and a single-element ultrasound transducer. Simultaneously measured local pulse wave velocity (PWV) and arterial dimensions were used in a mathematical model for calibration-free evaluation of local ?P. The proposed approach was initially verified using an arterial flow phantom, with invasive pressure catheter as the reference device. The developed porotype device was validated on 22 normotensive human subjects (age = 24.5 ± 4 years). Two independent measurements of local ?P from the carotid artery were made during physically relaxed and post-exercise condition. RESULTS:Phantom-based verification study yielded a correlation coefficient (r) of 0.93 (p < 0.001) for estimated ?P versus reference brachial ?P, with a non-significant bias and standard deviation of error equal to 1.11 mmHg and ±1.97 mmHg respectively. The ability of the developed system to acquire high-fidelity waveforms (dual MPG signals and ultrasound echoes from proximal and distal arterial walls) from the carotid artery was demonstrated by the in-vivo validation study. The group average beat-to-beat variation in measured carotid local PWV, arterial diameter parameters-distension and end-diastolic diameter, and local ?P were 4.2%, 2.6%, 3.3%, and 10.2% respectively in physically relaxed condition. Consistent with the physiological phenomenon, local ?P measured from the carotid artery of young populations was, on an average, 22 mmHg lower than the reference ?P obtained from the brachial artery. Like the reference brachial blood pressure (BP) monitor, the developed prototype device reliably captured variations in carotid local ?P induced by an external intervention. CONCLUSION:This technique could provide a direct measurement of local PWV, arterial dimensions, and a calibration-free estimate of beat-by-beat local ?P. It can be potentially extended for calibration-free cuffless BP measurement and non-invasive characterization of central arteries with locally estimated biomechanical properties.

Dataset Information

Digital arterial pressure pulse wave analysis and cardiovascular events in the general population: the Prevention of Renal and Vascular End-stage Disease study.

Publications

Digital arterial pressure pulse wave analysis and cardiovascular events in the general population: the Prevention of Renal and Vascular End-stage Disease study.

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