Growth hormone regulates intestinal gene expression of nutrient transporters in tilapia (Oreochromis mossambicus).

ABSTRACT: Among the various ways that growth hormone (GH) underlies the growth physiology of teleost fishes, GH stimulates transport pathways that facilitate the absorption of nutrients across intestinal epithelia. The current study investigated the effects of GH on the gene expression of nutrient transporters in an omnivorous teleost, the Mozambique tilapia (Oreochromis mossambicus). We employed pituitary gland removal (hypophysectomy) and hormone replacement to assess whether GH directs the gene expression of the GH receptor (ghr2), the peptide transporters, pept1a, pept1b and pept2, the amino acid transporter, slc7a9, the Na⁺/glucose cotransporter, sglt1, the glucose transporter, glut2, and the myo-inositol transporter, smit2, in anterior, middle, and posterior intestine. ghr2 was pred

SUBMITTER: Petro-Sakuma C 

PROVIDER: S-EPMC7253219 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature