Ontology highlight
ABSTRACT:
SUBMITTER: Panetta JC
PROVIDER: S-EPMC7253324 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Panetta John C JC Liu Yiwei Y Swanson Hope D HD Karol Seth E SE Pui Ching-Hon CH Inaba Hiroto H Jeha Sima S Relling Mary V MV
Pediatric blood & cancer 20200423 7
It is unclear if dosing intervals for Erwinase can be extended with intramuscular (i.m.) versus intravenous (i.v.) dosing. Children with acute lymphoblastic leukemia received Erwinase at 30 000-42 000 IU/m<sup>2</sup> i.v. or i.m. I.m. Erwinase (n = 22) achieved activity above 0.1 IU/mL for longer than i.v. Erwinase (n = 33) (3.4 vs 2.9 days, P = 0.0007). With 30 000 IU/m<sup>2</sup> Monday, Wednesday, Friday, more patients achieved adequate concentrations over the weekend with i.m. vs i.v. dosi ...[more]