Ontology highlight
ABSTRACT:
SUBMITTER: Goldfarb EV
PROVIDER: S-EPMC7253445 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Goldfarb Elizabeth V EV Rosenberg Monica D MD Seo Dongju D Constable R Todd RT Sinha Rajita R
Nature communications 20200527 1
Although the feeling of stress is ubiquitous, the neural mechanisms underlying this affective experience remain unclear. Here, we investigate functional hippocampal connectivity throughout the brain during an acute stressor and use machine learning to demonstrate that these networks can specifically predict the subjective feeling of stress. During a stressor, hippocampal connectivity with a network including the hypothalamus (known to regulate physiological stress) predicts feeling more stressed ...[more]