Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC7253463 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Communications biology 20200527 1
Cisplatin and other platinum-based compounds are frequently used to treat breast cancer, but their utility is severely compromised by drug resistance. Many genes dictating drug responsiveness are subject to pre-mRNA alternative splicing which is regulated by key kinases such as the serine-arginine protein kinase 1 (SRPK1). However, its contribution to drug resistance remains controversial. In this study, we have identified that Tip60-mediated acetylation of SRPK1 is closely associated with chemo ...[more]