Ontology highlight
ABSTRACT:
SUBMITTER: Foy JP
PROVIDER: S-EPMC7253757 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Foy Jean-Philippe JP Bertolus Chloé C Boutolleau David D Agut Henri H Gessain Antoine A Herceg Zdenko Z Saintigny Pierre P
Frontiers in oncology 20200521
In some western countries, an increasing incidence of oral squamous cell carcinoma (OSCC) has been observed in non-smoker non-drinker patients (NSND), mostly in women with HPV-negative OSCC. In the context of the unknown etiology and mechanisms of tumorigenesis of OSCC in NSND, we discuss data supporting the hypothesis of a viral origin not related to HPV. OSCC from NSND are characterized by an antiviral DNA methylation and gene expression signature. Based on the similar increasing incidence of ...[more]