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Cobalt-Catalyzed E-Selective Isomerization of Alkenes with a Phosphine-Amido-Oxazoline Ligand.

ABSTRACT: An efficient method to access (E)-trisubstituted alkenes is reported via cobalt-catalyzed isomerization of 1,1-disubstituted alkenes using a phosphine-amido-oxazoline ligand. The reaction could also convert mono- and 1,2-disubstituted alkenes to (E)-internal alkenes with benzylic selectivity. This protocol is atom-economy and operationally simple and uses readily available starting materials with good functional tolerance. This catalytic system could be scaled up to gram scale smoothly with a catalyst loading of 0.1 mol %.

SUBMITTER: Liu H 

PROVIDER: S-EPMC7254813 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Cobalt-Catalyzed <i>E</i>-Selective Isomerization of Alkenes with a Phosphine-Amido-Oxazoline Ligand.

Liu Hongmei H   Cai Cheng C   Ding Yanghao Y   Chen Jianhui J   Liu Bosheng B   Xia Yuanzhi Y  

ACS omega 20200512 20

An efficient method to access (<i>E</i>)-trisubstituted alkenes is reported via cobalt-catalyzed isomerization of 1,1-disubstituted alkenes using a phosphine-amido-oxazoline ligand. The reaction could also convert mono- and 1,2-disubstituted alkenes to (<i>E</i>)-internal alkenes with benzylic selectivity. This protocol is atom-economy and operationally simple and uses readily available starting materials with good functional tolerance. This catalytic system could be scaled up to gram scale smoo  ...[more]

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