Ontology highlight
ABSTRACT:
SUBMITTER: Howe LJ
PROVIDER: S-EPMC7254844 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Howe Laurence J LJ Dudbridge Frank F Schmidt Amand F AF Finan Chris C Denaxas Spiros S Asselbergs Folkert W FW Hingorani Aroon D AD Patel Riyaz S RS
Human molecular genetics 20200501 8
<h4>Background</h4>There is growing evidence that polygenic risk scores (PRSs) can identify individuals with elevated lifetime risk of coronary artery disease (CAD). Whether they can also be used to stratify the risk of subsequent events among those surviving a first CAD event remain uncertain, with possible biological differences between CAD onset and progression, and the potential for index event bias.<h4>Methods</h4>Using two baseline subsamples of UK Biobank: prevalent CAD cases (N = 10 287) ...[more]