Ontology highlight
ABSTRACT:
SUBMITTER: Rahman MA
PROVIDER: S-EPMC7254864 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Rahman Mohammad Aminur MA Wang Pengfei P Zhao Zhixiang Z Wang Dongsheng D Nannapaneni Sreenivas S Zhang Chao C Chen Zhengjia Z Griffith Christopher C CC Hurwitz Selwyn J SJ Chen Zhuo G ZG Ke Yonggang Y Shin Dong M DM
Angewandte Chemie (International ed. in English) 20171115 50
Short interfering RNA (siRNA) is a promising molecular tool for cancer therapy, but its clinical success is limited by the lack of robust in vivo delivery systems. Rationally designed DNA nanoparticles (DNPs) have emerged as facile delivery vehicles because their physicochemical properties can be precisely controlled. Nonetheless, few studies have used DNPs to deliver siRNAs in vivo, and none has demonstrated therapeutic efficacy. Herein, we constructed a number of DNPs of rectangular and tubula ...[more]