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Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives.

ABSTRACT: Therapeutic cancer vaccines are one of the most promising strategies of immunotherapy. Traditional vaccines consisting of tumor-associated antigens have met with limited success. Recently, neoantigens derived from nonsynonymous mutations in tumor cells have emerged as alternatives that can improve tumor-specificity and reduce on-target off-tumor toxicity. Synthetic peptides are a common platform for neoantigen vaccines. It has been suggested that extending short peptides into long peptides can overcome immune tolerance and induce both CD4+ and CD8+ T cell responses. This review will introduce the history of long peptide-based neoantigen vaccines, discuss their advantages, summarize current preclinical and clinical developments, and propose future perspectives.

SUBMITTER: Chen X

PROVIDER: S-EPMC7255011 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives.

Chen Xiaotong X Yang Ju J Wang Lifeng L Liu Baorui B

Theranostics 20200515 13

Therapeutic cancer vaccines are one of the most promising strategies of immunotherapy. Traditional vaccines consisting of tumor-associated antigens have met with limited success. Recently, neoantigens derived from nonsynonymous mutations in tumor cells have emerged as alternatives that can improve tumor-specificity and reduce on-target off-tumor toxicity. Synthetic peptides are a common platform for neoantigen vaccines. It has been suggested that extending short peptides into long peptides can o ...[more]

PMID: 32483434

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