Ontology highlight
ABSTRACT:
SUBMITTER: Yao Q
PROVIDER: S-EPMC7255488 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Yao Qing Q Khan Mohd Parvez MP Merceron Christophe C LaGory Edward L EL Tata Zachary Z Mangiavini Laura L Hu Jiarui J Vemulapalli Krishna K Chandel Navdeep S NS Giaccia Amato J AJ Schipani Ernestina E
Developmental cell 20190516 5
Oxygen (O<sub>2</sub>) is both an indispensable metabolic substrate and a regulatory signal that controls the activity of Hypoxia-Inducible Factor 1α (Hif1a), a mediator of the cellular adaptation to low O<sub>2</sub> tension (hypoxia). Hypoxic cells require Hif1a to survive. Additionally, Hif1a is an inhibitor of mitochondrial respiration. Hence, we hypothesized that enhancing mitochondrial respiration is detrimental to the survival of hypoxic cells in vivo. We tested this hypothesis in the fet ...[more]