Ontology highlight
ABSTRACT:
SUBMITTER: Garwain O
PROVIDER: S-EPMC7255494 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Garwain Osama O Yerramilli V Siddartha VS Romero Kate K Scarlata Suzanne S
Cellular signalling 20200401
Alzheimer's disease is typified by calcium dysfunction and neurofibrillary tangles of tau aggregates along with mitotic proteins. Using PC12 cells as a model system, we determined whether the Gαq/PLCβ/ calcium signaling pathway impacts the manifestation of Alzheimer's disease. Down-regulating PLCβ significantly increases tau protein expression and causes a large increase in tau aggregation. Stimulating Gαq to activate PLCβ results in a modest reduction in tau aggregation while inhibiting PLCβ ac ...[more]