Dataset Information

Genetic Heterogeneity of Australian Candida auris Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome Sequencing.

ABSTRACT: Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections.

SUBMITTER: Biswas C

PROVIDER: S-EPMC7255648 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Publications

Genetic Heterogeneity of Australian <i>Candida auris</i> Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome Sequencing.

Biswas Chayanika C Wang Qinning Q van Hal Sebastiaan J SJ Eyre David W DW Hudson Bernard B Halliday Catriona L CL Mazsewska Krystyna K Kizny Gordon Alice A Lee Andie A Irinyi Laszlo L Heath Christopher H CH Chakrabarti Arunaloke A Govender Nelesh P NP Meyer Wieland W Sintchenko Vitali V Chen Sharon C-A SC

Open forum infectious diseases 20200507 5

Whole-genome sequencing clustered Australian <i>Candida auris</i> isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigati ...[more]

PMID: 32500091

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Dataset Information

Genetic Heterogeneity of Australian Candida auris Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome Sequencing.

Publications

Genetic Heterogeneity of Australian <i>Candida auris</i> Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome Sequencing.

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