Dataset Information

Epileptic seizures triggered by eating in dogs.

ABSTRACT:

Background

Seizures triggered by eating (STE) behavior are very rare in humans and have not been documented previously in dogs.

Objectives

To document the occurrence of STE in dogs and describe their clinical features.

Animals

Ten client-owned dogs with STE diagnosed at 5 European referral centers.

Methods

A call for suspected cases of STE was made online. This call was followed by a retrospective review of medical records, combined with a questionnaire to be completed by both the owner and the board-certified neurologist who made the diagnosis. Cases were included if >50% of the seizures that occurred were related to eating and if a minimum diagnostic evaluation for seizures had been performed.

Results

Four cases only had STE and 6 cases had both STE and spontaneous seizures. Four of the dogs were retrievers. The most common seizure type was focal epileptic seizures evolving to become generalized. Nine dogs were diagnosed with idiopathic epilepsy. One dog had a presumptive diagnosis of glioma involving the margins of the parietal, temporal, and frontal cortex (the perisylvian region), an area known to have a key role in eating-associated epilepsy in people. Treatment strategies included a combination of pharmacological management and eating habit changes.

Conclusions and clinical importance

We have identified a form of reflex epilepsy in dogs, with STE behavior. Further studies are warranted to improve the characterization and management of STE.

SUBMITTER: Brocal J

PROVIDER: S-EPMC7255664 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Publications

Epileptic seizures triggered by eating in dogs.

Brocal Josep J Lowrie Mark M Wamsley Gemma G Cauduro Alberto A Mandigers Paul P Gutierrez-Quintana Rodrigo R Stalin Catherine C

Journal of veterinary internal medicine 20200428 3

<h4>Background</h4>Seizures triggered by eating (STE) behavior are very rare in humans and have not been documented previously in dogs.<h4>Objectives</h4>To document the occurrence of STE in dogs and describe their clinical features.<h4>Animals</h4>Ten client-owned dogs with STE diagnosed at 5 European referral centers.<h4>Methods</h4>A call for suspected cases of STE was made online. This call was followed by a retrospective review of medical records, combined with a questionnaire to be complet ...[more]

PMID: 32343869

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Project description:It is generally understood that there is a preictal phase in the development of a seizure and this precictal period is the basis for seizure prediction attempts. The focus of this study is the preictal global spatiotemporal dynamics and its intra-patient variability. We analyzed preictal broadband brain connectivity from human electrocorticography (ECoG) recordings of 185 seizures (which included 116 clinical seizures) collected from 12 patients. ECoG electrodes record from only a part of the cortex, leaving large regions of the brain unobserved. Brain connectivity was therefore estimated using the sparse-plus-latent-regularized precision matrix (SLRPM) method, which calculates connectivity from partial correlations of the conditional statistics of the observed regions given the unobserved latent regions. Brain connectivity was quantified using eigenvector centrality (EC), from which a degree of heterogeneity was calculated for the preictal periods of all seizures in each patient. Results from the SLRPM method are compared to those from the sparse-regularized precision matrix (SRPM) and correlation methods, which do not account for the unobserved inputs when estimating brain connectivity. The degree of heterogeneity estimated by the SLRPM method is higher than those estimated by the SRPM and correlation methods for the preictal periods in most patients. These results reveal substantial heterogeneity or desynchronization among brain areas in the preictal period of human epileptic seizures. Furthermore, the SLRPM method identifies more onset channels from the preictal active electrodes compared to the SRPM and correlation methods. Finally, the correlation between the degree of heterogeneity and seizure severity of patients for SLRPM and SRPM methods were lower than that obtained from the correlation method. These results support recent findings suggesting that inhibitory neurons can have anti-seizure effects by inducing variability or heterogeneity across seizures. Understanding how this variability is linked to seizure initiation may lead to better predictions and controlling therapies.

Dataset Information

Epileptic seizures triggered by eating in dogs.

Background

Objectives

Animals

Methods

Results

Conclusions and clinical importance

Publications

Epileptic seizures triggered by eating in dogs.

Similar Datasets

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