Ontology highlight
ABSTRACT:
SUBMITTER: An Y
PROVIDER: S-EPMC7256208 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
An Yong Y Chang Wei W Wang Wei W Wu Hao H Pu Ke K Wu Anhu A Qin Ze Z Tao Yan Y Yue Zhongjin Z Wang Peng P Wang Zhiping Z
Journal of advanced research 20200428
Zinc as a biomarker can be used to diagnose the early stage prostate cancer, while ZIP1 protein, a zinc transporter is significantly down-regulated in prostate cancer cells. This behavior leads to the apparent alteration of the enrichment ability for zinc between early prostate cancer tissues and healthy tissues. This difference inspires us to develop a novel Zn<sup>2+</sup> sensor that applies to the clinic diagnosis of early prostate cancer. We designed a tetrapeptide sensor <b>H<sub>2</sub>L< ...[more]